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What Drugs Should Not Be Taken With CBD?

What Drugs Should Not Be Taken With CBD?

Modern medicine offers a solution for almost every problem. Common complaints like headaches, stomach distress, anxiety, and many other issues can be treated with prescription or over-the-counter drugs. Millions of people are living better lives thanks to these medical advances! 

However, the pharmaceutical industry’s continued growth has prompted many people to conduct more research on natural alternatives. Some plant-based or traditional treatments have shown excellent clinical results like medical cannabis and other cannabinoid medications like CBD. 

CBD is one example of a “folk cure” that’s been confirmed by rigorous scientific studies. When taken on its own, CBD side effects are almost non-existent in CBD-only products. However, there are some risks to mixing CBD oil with other substances. 

Learn more about how CBD interacts with multiple medications, combining CBD and other prescription medications, including avoiding certain drug mixtures and questions to ask your doctor about possible interactions between CBD and certain substances.


Common Drug Interactions and CBD

Potential drug interactions are a risk whenever you simultaneously take two or more prescribed medications. There’s a reason why your doctor wants to know what medicines you’re taking when they write a new prescription. Some drugs are perfectly safe on their own, yet cause dangerous interactions and health conditions with other prescription medications.

The same effect can also happen with vitamins and natural supplements, including CBD oil. Anything you take could interact with your other medications. Before adding this substance to your routine, you should talk to your doctor about potential CBD side effects. CBD is very effective for many people, but it’s essential to research before mixing CBD and other supplements.

Explore details on common interactions between CBD oil and other drugs and prescription medication

For now, let’s look at CBD’s interaction with several medications commonly found in most households. 

Common Drug Interactions And CBD

CBD And Ibuprofen

Ibuprofen is a non-steroidal anti-inflammatory drug, also known as an NSAID. Many people use ibuprofen to treat pain or inflammation. However, this drug can cause nausea, dizziness, and difficulty breathing in people who are allergic to ibuprofen or have taken too much. 

CBD oil side effects on ibuprofen include extending how long ibuprofen lasts in the body. This effect can cause dangerous reactions if you take another dose before the first one has worn off.


CBD And Tylenol

Tylenol or acetaminophen is a common pain and fever reliever that has effects on liver enzymes and how a liver breaks CBD down. Tylenol can cause liver damage, headaches, insomnia, nausea, and raise concerns if abused. 

Tylenol, CBD and other drugs are all metabolized by the enzyme CYP450. As a result, these compounds can become less effective when taken together since the same enzyme digests them. Some studies have also shown that large doses of CBD oil can increase liver damage caused by Tylenol in rats.


CBD And Aspirin

Aspirin is another common pain killer. Be very careful not to mix aspirin and CBD in large amounts to avoid unwanted drug interaction.

CBD side effects can include:

  • Brain bleeding
  • Stomach issues
  • Sleepiness
  • Gastritis
  • Intestinal bleeding
  • Heartburn
  • Nosebleeds
  • Headaches 

Questions To Ask Your Doctor About CBD

Before using CBD products, you should learn about potential CBD drug interactions and side effects. Then, an excellent medical professional willl be able to discuss your options in an open, non-judgmental way. Here are some questions to help get the conversation going on CBD interactions with different medications and supplements like SOS pills.CBD Drug Interactions

What Type Of CBD Product Is Best For My Condition?

There is a range of CBD products currently on the market. However, some products will better fit your needs depending on your situation. For example, if you’re struggling with localized pain, CBD topicals might be the best choice for you.

On the other hand, anxiety patients are often better served by CBD edibles or tinctures. But, again, your doctor should be able to help you discover the best choice.


How Will CBD Interact With My Prescription Drugs?

Potential CBD side effects are very important to uncover. Certain medications shouldn’t be taken together because they cause harmful or dangerous interactions. Supplements like CBD can cause the same effect. Discuss your current medications and supplements with your doctor to see if CBD could cause unintended drug interactions.


How Much CBD Oil Should I Take?

Your ideal CBD dose depends on many factors. First, the type of product you’re using plays an important role. CBD products like topicals, edibles, capsules, tinctures, and more have specific dosages. Second, your biochemistry also determines your best dose. Finally, your over health, weight, cannabis experience and other medications impact your dose.


Will CBD Make Me Fail A Drug Test?

Drug tests are an unpleasant necessity for some people. However, if your job, school, sports team, or other organization requires regular drug tests, you’re probably wondering if CBD will make you fail your drug test. CBD is extracted from cannabis plants, after all.

It all depends on what compounds are present in your CBD. Pure CBD isolates and broad-spectrum products shouldn’t contain any THC. However, some full-spectrum CBD products do contain THC at higher levels. Your doctor can help you find low-THC products that will help you benefit from CBD while still passing your drug tests.


In Conclusion On CBD Drug Interactions, CBD and Prescription Medications

Now that we know what drugs should not be taken with CBD because of the potential CBD interaction with over-the-counter medications and prescription drugs, you are better equipt for taking CBD oil safely for potential health benefits. In addition, when taken correctly, the therapeutic compounds of CBD oils can help with things like pain relief, as an example of a medical condition that benefits from CBD use. 

Lastly, make sure to find CBD Online from trusted sources so you can get high-quality and effective products like those like BioLyfe Nutritional Supplements. Buy CBD online in Canada from a reliable online dispensary in Canada so that you can take CBD with confidence. 



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BioLyfe. (2022, August 17). Buy All-Natural Plant-Based Dietary Supplements. Available at:

Mouslech, Z. (2009). Endocannabinoid system: An overview of its potential in current medical practice. National Library of Medicine National Center for Biotechnology Information. Available at: Available At:

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Ferber SG, Namdar D, Hen-Shoval D, Eger G, Koltai H, Shoval G, Shbiro L, Weller A. The “Entourage Effect”: Terpenes Coupled with Cannabinoids for the Treatment of Mood Disorders and Anxiety Disorders. Curr Neuropharmacol. 2020;18(2):87-96. DOI: 10.2174/1570159X17666190903103923. PMID: 31481004; PMCID: PMC7324885. Available at:

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